Pre-Test Optimizing Complement Inhibition for Paroxysmal Nocturnal Hemoglobinuria: A Focus on Novel Therapies and Managed Care Opportunity Pre-Test Why are red blood cells particularly sensitive to genetic alterations in the complement system? Red blood cells are continuously exposed to the complement system, as part of the body’s pathogen response. Red blood cells can change their geometry, increasing cell flexibility and creating high cellular surface area-to-volume ratios. Red blood cells are involved in tissue protection and regulation of cardiovascular homeostasis. Red blood cells help maintain hemoglobin in the reduced state, which is necessary to prevent lysis. Unsure Which of the following is the only curative treatment for PNH? Blood transfusion Bone marrow transplant C3 complement inhibition C5 complement inhibition Unsure Which of the following agents acts on C3, where the three pathways of the complement cascade merge? Danicopan Eculizumab Pegcetacoplan Ravulizumab Unsure Complement inhibitors are associated with increased risk of which of the following Influenza infection Meningococcal infection Pneumonia Shingles Unsure
