Pre-Test Current and Emerging Management Strategies in Chronic Cough: A Common Complaint with Complex Causes Pre-Test Which of the following molecular receptors responds to ATP, activates vagal sensory nerves, and plays a primary role in the cough reflex? AChR Histamine receptors P2X3 TRPV1 Unsure According to ACCP/CHEST guidelines, which of the following best defines chronic cough? Biopsy-identified chronic hypersensitivity of the mucosa neurons Cough lasting longer than 8 weeks in adults and 4 weeks in children Coughing frequency that exceeds 1,000 coughs per day Coughing that interferes with work and/or social activities Unsure Which of the following investigational agents, studied in the COUGH-1 and COUGH-2 phase 3 trials, is a P2X3 receptor antagonist that resulted in a significant reduction in 24-hour cough frequency compared to placebo? BLU-5937 Gefapixant Orvepitant Sivopixant Unsure How confident are you in your ability to identify the underlying causes of chronic cough and recommend guideline-directed care? Very confident Confident Somewhat confident Not very confident Not at all confident
